After going down in a thriller to Parramatta, Penrith's premiership credentials will be further examined when they face a Storm side shooting for three wins in a row.
The Panthers will have learned lessons after squandering a 10-0 lead against the undefeated Eels, while Melbourne look dangerous having adjusted to the new six-again rule.
The Storm have been a bogey team for Penrith, beating them in 18 of their past 20 meetings dating back to 2006. The Panthers last trumped Melbourne in 2018.
Panthers: The Panthers will start the match 1-17 after Jack Hetherington and Caleb Aekins were the last two omitted. Dylan Edwards returns from injury at fullback. Liam Martin replaces the injured Kurt Capewell in the back row and Billy Burns joins the interchange. Mitch Kenny and Brent Naden were the players to make way from the initial 21-man squad on Thursday. The Panthers have won only two of their past 20 games against the Storm.
Storm: Marion Seve will start in the wing spot vacated by Josh Addo-Carr - who is expecting the birth of his child and is out of the side. Paul Momirovski, who was initially named to replace Addo-Carr, is out of the team. He and Max King were the last two players dropped from the squad. For the third straight week, Brandon Smith will start at prop, with Christian Welch dropping back to the bench. Jahrome Hughes (broken hand) was cut from the extended squad a day before kick-off. The Storm have won four from four at Campbelltown Stadium.
He turns 37 on Thursday, but Cameron Smith is still very much elite. The Storm hooker was outstanding against Newcastle, proving he can use his unparalleled game smarts to thrive under the six-again rule. Meanwhile, Api Koroisau is a focal point of Penrith's attack and always dangerous from dummy-half.