The Thunderbolts' suffered their first loss since Round 13, succumbing to a late penalty goal against Wests Tigers on Saturday afternoon at Campbelltown.
Matt Adamson's side overturned an early deficit, finding themselves 12-0 down before fighting back either side of the half-time break.
A stunning period of play saw the Thunderbolts put on four unanswered tries with forwards Dean Britt and Joe Stimson leading the charge. Front-rower Nelson Asofa-Solomona also continued his recent try-scoring form, bagging a double.
With Melbourne carrying a narrow advantage into the dying stages of the match, the hosts levelled the scores setting up a grandstand finish.
A late penalty goal to the Tigers sealed Melbourne's fate with the Thunderbolts' six game winning run coming to an end. Melbourne now sit in seventh place on the NYC Cup table, two points clear of the eighth placed Warriors.
The Thunderbolts will travel to Newcastle in Round 22 to face the Knights at Hunter Stadium from 1:10pm.
Melbourne Storm 22
Tries: Nelson Asofa-Solomona, Dean Britt, Joe Stimson
Goals: Brayden Torpy 3
Wests Tigers 24
Tries: Tyler Cassel, John Tohi, John Ogden, Delouise Hoeter
Goals: Eli Levido 4